systemK11

Modern pharmacology for hair transplant patients

Biotechnology for chronic, progressive hair loss — developed by Systems Trichology London for hair restoration clinics.

  • Chemical structure of dihydroberberine
  • Chemical structure of ergothioneine
  • Chemical structure of procyanidin B2, a B-type proanthocyanidin
  • Chemical structure of sulforaphane
  • Chemical structure of galactomannan, the fibre in fenugreek seed
  • Chemical structure of dihydroberberine
  • Chemical structure of ergothioneine
  • Chemical structure of procyanidin B2, a B-type proanthocyanidin
  • Chemical structure of sulforaphane
  • Chemical structure of galactomannan, the fibre in fenugreek seed
  • Chemical structure of dihydroberberine
  • Chemical structure of ergothioneine
  • Chemical structure of procyanidin B2, a B-type proanthocyanidin
  • Chemical structure of sulforaphane
  • Chemical structure of galactomannan, the fibre in fenugreek seed

Beyond Conventional Hair Loss Solutions

systemK11

Minoxidil & finasteride

Non-medical

Backed by RCTs & modern discoveries published in high-ranking journals

Developed by pharmaceutical companies in the 1950s and 1970s

No publications or in low-ranking, paid journals

Targets hair follicle glucose metabolism & TGF-beta signalling proteins

Target K+ ion channels and 5-alpha reductase II respectively

Rarely defined targets

Used by hair transplant patients and those with progressive and chronic hair loss.

Used by hair transplant patients and those with progressive and chronic hair loss.

Used for nutrient and stress related hair loss

Naturally found in our bodies and diets. Used for longevity optimisation

Lab-designed drugs, small risk of serious side effects

Found in food and cosmetics

Standardised, pharmaceutical-strength active ingredients

Standardised, pharmaceutical-strength active ingredients

Rarely standardised

systemK11

Minoxidil &
finasteride

Non-medical

Backed by RCTs & modern discoveries published in high-ranking journals

Targets hair follicle glucose metabolism & TGF-beta signalling proteins

Used by hair transplant patients and those with progressive and chronic hair loss.

Naturally found in our bodies and diets. Used for longevity optimisation

Standardised, pharmaceutical-strength active ingredients

Tap options to compare

Translating breakthrough research into real-world technology that reaches patients

Regulated hair follicle glucose metabolism

Hair loss has been associated with high-sugar consumption, hyperglycaemia and type 2 diabetes. systemK11 ingredients target unregulated glucose metabolism in balding hair follicles.

Enhanced mitochondrial protection

Gene expression studies revealed mitochondria become damaged in miniaturising follicles. In systemK11 ergothioneine is transported into mitochondria and helps improve hair loss outcomes, even in advanced stages.

Diagram of glucose metabolism in the balding scalp: excess glucose saturates hexokinase and is diverted into the polyol pathway; with HIF-1α and LDH-A inactive, lactate stays low while citric-acid-cycle activity, mitochondrial load and reactive oxygen species rise.

Dysregulated glucose metabolism affects hair health. High glucose levels activate polyol pathway, leading to burnt out mitochondria and depleted glycogen reserves, shortening the anagen phase and accelerating miniaturisation.
Source: Sadgrove, N., Batra, S., Barreto, D. and Rapaport, J., 2023. An updated etiology of hair loss and the new cosmeceutical paradigm in therapy: Clearing ‘the big eight strikes’. Cosmetics, 10(4), p.106.

TGF-β1 modulation

TGF-β1 mediates perifollicular fibrosis in a high DHT/Reactive oxygen species (ROS) environment and leads to miniaturisation. Without it, DHT encourages hair growth, such as on the beard or chest.

Flowchart from English (Medical Hypotheses, 2018): the androgen response raises TGF-β1, driving perifollicular fibrosis, dermal-sheath thickening and blood-vessel calcification that cut blood flow and oxygen and lead to hair-follicle miniaturisation; finasteride targets the androgen response and minoxidil targets blood flow.

The proposed role of TGF-β1 and its interplay with DHT in hair loss progression, helping explain the androgen paradox.
Source: English Jr, R.S., 2018. A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors. Medical Hypotheses, 111, pp.73-81.

The proof is in the numbers

Bar chart (Schulz et al., 2006, fenugreek plus micronutrients vs placebo): distribution of hair-improvement scores after 6 months; placebo scores clustered at 0–1, supplement scores mostly 1–2.
Bar chart (Beoy et al., 2010): hair count per cm² at months 0, 4 and 8; the tocotrienol group rose while placebo stayed flat.
Bar chart (Tenore et al., 2018): hair number per cm² and hair weight rising over months 0, 1 and 2 with an apple-procyanidin supplement.
Bar chart: hair number per cm² at months 0, 2 and 6, procyanidin B2 versus placebo.

Study 1: In a six-month randomised, placebo-controlled clinical trial of 60 participants

Ingredients in systemK11 improved hair density at parting region by retrospective assessment versus placebo. The study also showed a significant (p<0.045) improvement in photographic hair density parameters from image analysis.

Full Sample Analysis: 60 participants equally comprising men and women were randomised to placebo (1/3 of volunteers of each sex) or treatment group (2/3 of volunteers of each sex) and ingested capsules for 6 months and were examined photographically and given questionnaires. Formulation: SystemK11 contains two types of extracts of fenugreek seed optimising for respective key components. Source: Schulz et al. Fenugreek+ micronutrients: Efficacy of a food supplement against hair loss. Kosmetische Medizin. 2006;27(4):176-9.

Study 2

Study 3

Study 4

Bar chart (Schulz et al., 2006, fenugreek plus micronutrients vs placebo): distribution of hair-improvement scores after 6 months; placebo scores clustered at 0–1, supplement scores mostly 1–2.
Bar chart (Beoy et al., 2010): hair count per cm² at months 0, 4 and 8; the tocotrienol group rose while placebo stayed flat.
Bar chart (Tenore et al., 2018): hair number per cm² and hair weight rising over months 0, 1 and 2 with an apple-procyanidin supplement.
Bar chart: hair number per cm² at months 0, 2 and 6, procyanidin B2 versus placebo.

Study 1: In a six-month randomised, placebo-controlled clinical trial of 60 participants

Ingredients in systemK11 improved hair density at parting region by retrospective assessment versus placebo. The study also showed a significant (p<0.045) improvement in photographic hair density parameters from image analysis.

Full Sample Analysis: 60 participants equally comprising men and women were randomised to placebo (1/3 of volunteers of each sex) or treatment group (2/3 of volunteers of each sex) and ingested capsules for 6 months and were examined photographically and given questionnaires. Formulation: SystemK11 contains two types of extracts of fenugreek seed optimising for respective key components. Source: Schulz et al. Fenugreek+ micronutrients: Efficacy of a food supplement against hair loss. Kosmetische Medizin. 2006;27(4):176-9.

Study 2

Study 3

Study 4

Developed by the top 2% of published scientists

Recognized by Stanford University as a top 2% published scientist in medicinal and biomolecular chemistry (2023 and 2024), our Chief Science Officer and co-founder, Dr. Nicholas J. Sadgrove, is a pioneer in hair loss research and nutraceutical innovation with work featured in Nature.

Developed by the top 2% of published scientists

Recognized by Stanford University as a top 2% published scientist in medicinal and biomolecular chemistry (2023 and 2024), our Chief Science Officer and co-founder, Dr. Nicholas J. Sadgrove, is a pioneer in hair loss research and nutraceutical innovation with work featured in Nature.

Developed by the top 2% of published scientists

Recognized by Stanford University as a top 2% published scientist in medicinal and biomolecular chemistry (2023 and 2024), our Chief Science Officer and co-founder, Dr. Nicholas J. Sadgrove, is a pioneer in hair loss research and nutraceutical innovation with work featured in Nature.

Professional partners

Surgeons, dermatologists & trichologists

Surgeons, dermatologists & trichologists

  • Portrait of Dr. Fahad Al-Mutawa, consultant dermatologist

    Dr. Fahad Al-Mutawa

    Dr. Fahad, MD FRCPC FAAD DABD, is a consultant in dermatology, laser and hair with more than 20 years of experience, certified by both the Canadian and American Boards of Dermatology. He is a professor at the Faculty of Medicine of Kuwait University and established MySkin Clinic, one of the largest clinics in the State of Kuwait.

  • Portrait of Dr Joshua Crose, founder of Capitis Medical & Aesthetics

    Dr Joshua Crose

    Dr. Joshua Crose, an Osteopathic Physician and the founder of Capitis Medical & Aesthetics, is a member of the ISHRS. Specializing in Hair Restoration and Regenerative Medicine, he was named Physician of the Year by Dignity Health. He offers advanced hair transplantation and regenerative treatments for top-tier care.

  • Portrait of Dr. Faisal Salim, plastic surgeon

    Dr. Faisal Salim

    Dr. Faisal, a UK-trained plastic surgeon in Dubai, specializes in advanced FUE hair restoration. His bio-enhanced FUE method ensures exceptional graft quality with minimal follicle damage. Educated at St George’s, University of London and trained in the UK, Sweden, and USA, his qualifications include FRCS, MRCS, and CCT in Plastic Surgery. Dr. Faisal personally consults with patients, guiding their hair restoration journey.

  • Portrait of Dr Samuel Ghani, co-founder of Rejuvence Clinic, London

    Dr Samuel Ghani

    Dr. Ghani, MBBS BSc MRCSEd MScAesth FRCEM, co-founder of Rejuvence Clinic in London, qualified as a doctor in 2004 from GKT Medical School of King's College London. He earned a Masters in Aesthetic Medicine with distinction and is a member of the Royal College of Surgeons of Edinburgh. He has published and presented research at scientific conferences globally.

  • Portrait of Dr. Imran Tahir, plastic surgeon

    Dr. Imran Tahir

    Dr. Imran Tahir, M.B., B.S., F.R.C.S., Dip-Plast CSTRCS (England), is a renowned Plastic Surgeon with 20+ years of experience. He holds fellowships from the Royal Colleges of Surgeons in Glasgow, Ireland, and England. Trained in the UK, Australia, and Ireland, he has worked at St Andrew’s Center in Essex and Radcliffe Hospital in Oxford. He also has private practices in London and Harley Street.

  • Portrait of Adil Chowdry, hair-restoration clinic director

    Mr. Adil Chowdry

    Adil H. Chowdry, a veteran in medical aesthetics and hair restoration with 15+ years' experience, established a leading UAE clinic. He works with a top team, managing daily operations, staff recruitment, and regulatory compliance. Known for his expertise in patient care and medical protocols, Adil is a visionary leader driven by excellence and strong communication skills.

  • Portrait of Lisa Frehner, trichologist at Restore Hair and Scalp Clinic

    Lisa Frehner IAT

    Lisa Frehner is a certified Trichologist by the International Association of Trichology with deep knowledge and expertise in treating hair loss conditions. At Restore Hair and Scalp Clinic, she identifies root causes of hair loss and offers personalized solutions. Her comprehensive services include trichology consultations, hair enhancements, and low-level laser therapy, promoting optimal hair and scalp health.

  • Portrait of Dr. Maha Salama

    Dr. Maha Salama

    Dr. Maha is managing director of MS Healthcare, a medical product and pharmaceutical supplier for the GCC region. She specialises in dermatology and cosmetic laser technology, with over 15 years in the field earning patients' trust and respect thanks to her work ethic and enthusiasm.

  • Portrait of Gregorio Ruggeri, certified trichologist, Salon Ruggeri NYC

    Gregorio Ruggeri NYC

    Gregorio is a certified trichologist and founder of Salon Ruggeri NYC — voted best salon in New York by Time Out. With 30 years of experience since founding the appointment-only salon, he has also been featured in Allure, Harper’s Bazaar, W, Vanity Fair and Beauty Inc.

Systems Trichology London logo

Our Partner Clinics

Our Partner Clinics

Our Partner Clinics

Teams of top professionals around the world, ready to take hair care to the next level.

Teams of top professionals around the world, ready to take hair care to the next level.

Systems Trichology London logo
Systems Trichology London logo
Dr. Top Hair Hospital logo
Dr. Top Hair Hospital logo
The Skin Group laser, aesthetic and medical clinic logo
The Skin Group laser, aesthetic and medical clinic logo
Capitis Medical & Aesthetics logo
Capitis Medical & Aesthetics logo
Capitis Medical & Aesthetics logo
Capitis Medical & Aesthetics logo
Capitis Medical & Aesthetics logo
MySkin clinic logo
MySkin clinic logo
MySkin clinic logo
Rejuvence Clinic logo
Rejuvence Clinic logo
Rejuvence Clinic logo
Restore Hair and Scalp clinic logo
Restore Hair and Scalp clinic logo
Restore Hair and Scalp clinic logo

Active nutraceutical ingredients may also support healthier:

Active nutraceutical ingredients may also support healthier:

Blood sugar levels: contains a high-absorption form of berberine, linked to healthy glucose metabolism in multiple studies.

Heart health and lifespan: features ergothioneine linked to supporting longevity in large long-term studies.

Blood pressure: includes sulforaphane, linked to healthy blood pressure in multiple studies.

UNISEX • VEGAN • NATURE BASED

UNISEX • VEGAN • NATURE BASED

MEDICATION-FREE • PATENT PENDING

MEDICATION-FREE • PATENT PENDING

Open bottle of systemK11 targeted hair nutraceutical, a dietary supplement of 120 tablets
Open bottle of systemK11 targeted hair nutraceutical, a dietary supplement of 120 tablets

Doing better, not more

Doing better, not more

Since 2019, we’ve dedicated ourselves to the meticulous development of biotechnology for chronic and progressive hair thinning.

Time-tested ingredients derived from food origins

Compliant, study-based doses that actually make a difference

Made in the USA in a triple-certified US FDA cGMP facility

Choose an option

Proven discoveries, discreetly delivered

Monthly Delivery

Save 10% & shipping

30-day supply delivered each month.

$87

$97

Pause or cancel anytime.

3-Month Delivery

Save 15% & shipping

90-day supply delivered every 3 months.

$247

$291

Pause or cancel anytime.

6-Month Delivery

Save 20% & shipping

180-day supply delivered every 6 months.

$466

$582

Pause or cancel anytime.

FAQs

How long does it take for K11 to show results?

How was K11 designed to support hair transplant patients?

How should I take systemK11?

Does systemK11 require a prescription?

Who is systemK11 designed for?

What are the standards behind systemK11's production?

What does systemK11 contain?

Does systemK11 include drugs like minoxidil or finasteride?

Can systemK11 be combined with finasteride or minoxidil?

Why is biotin not included in systemK11?

FAQs

How long does it take for K11 to show results?

How was K11 designed to support hair transplant patients?

How should I take systemK11?

Does systemK11 require a prescription?

Who is systemK11 designed for?

What are the standards behind systemK11's production?

What does systemK11 contain?

Does systemK11 include drugs like minoxidil or finasteride?

Can systemK11 be combined with finasteride or minoxidil?

Why is biotin not included in systemK11?

FAQs

How long does it take for K11 to show results?

How was K11 designed to support hair transplant patients?

How should I take systemK11?

Does systemK11 require a prescription?

Who is systemK11 designed for?

What are the standards behind systemK11's production?

What does systemK11 contain?

Does systemK11 include drugs like minoxidil or finasteride?

Can systemK11 be combined with finasteride or minoxidil?

Why is biotin not included in systemK11?

Systems Trichology London Ltd · Est. 2019 · Registered in England and Wales, company no. 12114910

Systems Trichology US Corporation · Incorporated in Delaware

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Systems Trichology London Ltd · Est. 2019 · Registered in England and Wales, company no. 12114910

Systems Trichology US Corporation · Incorporated in Delaware

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Systems Trichology London Ltd · Est. 2019 · Registered in England and Wales, company no. 12114910

Systems Trichology US Corporation · Incorporated in Delaware

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.