TGF-β1 modulation
Proanthocyanidins
Statistically significant results in several modern randomised controlled trials [1,2,3] show B-type proanthocyanidins help increase hair counts, for example it helped increased hair weight by 37% over two months in a clinical trial, n=250 [1]. The proanthocyanidin targets TGF-β1 [4] which mediates perifollicular fibrosis in a high DHT environment, leading to miniaturisation [5].
SystemK11 contains the highest dose of proanthocyanidin-enriched extract on the market, in accordance with the studies. It is further enhanced with the use of piperine (BioPerine®) to increase its bioavailability.
References
Regulated hair follicle glucose metabolism
Dihydroberberine (GlucoVantage®) &
Dual fenugreek seed extracts
In 2023, high-power studies independently linked balding to sugary beverage consumption in 1,028 male participants [1] and to type 2 diabetes in 519 women in multi-variate analysis [2]. Berberine supports healthy glucose levels in meta analyses [3,4] and normalised polyol pathway activation [5], supporting energy stores in growing hair follicles [6,7]. A derivative of berberine, dihydroberberine enhances bioavailability, allowing for far lower dosages while maintaining its effectiveness [8].
Fenugreek has long been used in traditional hair loss therapy, with modern scientific corroboration in humans [9,10]. Vitexin [11] and 4-hydroxyisoleucine [12] are key components in extracts. SystemK11 also includes a galactomannan-rich fenugerek seed extract which confers a prebiotic effect and regulates glucose spikes in digestion [13].
References
Enhanced mitochondrial protection
Ergothioneine (MitoPrime®)
L-ergothioneine, a highly potent antioxidant [1], has been clinically observed to produce significant hair health improvements [2] by directly targeting mitochondrial damage. This damage is induced by reactive oxygen species, the byproducts of unregulated aerobic respiration that contribute to the balding process [3,4], as evidenced by the oxidative stress markers found in miniaturising hair follicles compared to their non-miniaturising counterparts [5]. Its half-life of 30 days [6], coupled with its transport to mitochondria via specific proteins [7], positions l-ergothioneine as an unparalleled compound for long-term hair maintenance and protection.
While pharmaceutical drugs like JXL069 are in development for the mitochondrial component of hair loss, systemK11 offers a safe, next-generation nutraceutical solution for patients today.
References
Autologous degradation of DHT facilitated
Sulforaphane glucosinolate (Activated BroccoRaphannin®)
Statistically significant outcomes in hair count have been achieved with sulforaphane in various studies [1,2], including human trials [3]. The compound supports the expression of the enzyme 3α-hydroxysteroid dehydrogenase, which breaks down DHT into less harmful metabolites.
Sulforaphane, due to its natural instability, is administered in systemK11 as a stable precursor called sulforaphane glucosinolate. This is paired with the myrosinase enzyme, which activates the sulforaphane at the time of delivery. This method guarantees consistently high bioavailability of the active compound for the patient.
References
Elemental magnesium 350mg
Genistein, glycetein & daidzein
Hedging gently against long-term deficiencies
